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3T Diffusion Weighted MR Imaging in Diagnosing Extrahepatic Cholangiocarcinoma

[ Vol. 13 , Issue. 4 ]

Author(s):

Xiaoping Yang, Ke Ren*, Wenge Sun, Xixun Qi, Yongfeng Wang, Jingang Chu and Ke Xu*   Pages 406 - 412 ( 7 )

Abstract:


Objectives: To evaluate the incremental value of diffusion weighted imaging (DWI) in addition to magnetic resonance cholangiopancreat-ography (MRCP) in diagnosing extrahepatic cholangiocarcinoma (EHCC); to determine the most appropriate b value for DWI on 3.0 T MRI.

Methods: Preoperative MRI examinations were performed for 63 patients with suspected EHCC. The examinations included T2-weighted imaging, coronal fast imaging employing steady-state acquisition (FIESTA), MRCP and DWI sequence with different b values (500, 1000 and 1200s/mm2). All cases were confirmed by histopathological diagnosis. Two radiologists in consensus reviewed MRCP imaging and combined MRCP and DWI imaging with ADC maps, and apparent diffusion coefficient (ADC) value, signal-noise ratio (SNR), contrast-to-noise ratio (CNR) and signalintensity ratio (SIR) under various b values were calculated.

Results: There were significant differences in sensitivity (74.4% vs. 94.9%), specificity (75% vs. 100%) and accuracy (74.6% vs. 96.8%) between MRCP alone and combined MRCP and DWI with a b value of 1000 s/mm2 (P<0.05). There was also a significant difference in ADC, SNR, CNR and SIR under various b values (P<0.05).

Conclusion: For diagnosing EHCC, the combined use of MRCP and DWI shows a better diagnostic performance than MRCP alone; the b value of 1000 s/mm2 is the most appropriate for DWI on 3.0T MRI.

Keywords:

Cholangiocarcinoma, diffusion magnetic resonance imaging, magnetic resonance imaging, magnetic resonance cholangiopancreatography, FIESTA, SIR, CNR, ADC.

Affiliation:

Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang City, Liaoning Province, Department of Radiology, the First Affiliated Hospital of China Medical University, No. 155, Nanjing Street, Heping District, Shenyang City, Liaoning Province, Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang City, Liaoning Province, Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang City, Liaoning Province, Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang City, Liaoning Province, Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang City, Liaoning Province, Department of Radiology, the First Affiliated Hospital of China Medical University, No. 155, Nanjing Street, Heping District, Shenyang City, Liaoning Province

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