Giuseppe Corrias*, Antonella Balestrieri, Carola Politi, Luigi Barberini and Luca Saba Pages 887 - 898 ( 12 )
Introduction: Metabolome reflects the sum of all life processes in the cell-tissue-organ, belonging to all the systems that constitute the individual and it refers to metabolites included in a cell, tissue or organism. Since metabolites are various, in terms of chemical species and concentrations, it is necessary to conduct metabolite analysis with a variety of different analytical techniques. Imaging is the main part of these modern diagnosis pathways.
Discussion: A narrative review of all the relevant papers known to the authors was conducted, researching the Pubmed database. Considering this last definition of the multimodal in vivo - in vitro approach, an essential and versatile diagnostic technique can be regarded as the most recent and crucial innovation in modern diagnostics: Nuclear Magnetic Resonance (NMR).
For the in vitro application, NMR has become an important tool for metabolomics. Metabolomics is defined as the quantitative and qualitative analysis of a large number of metabolites that are intermediate or final products of all the metabolic pathways in a biological system. Metabolomics aims to obtain a global understanding of living organisms to a deeper level than has so far been achieved through genomics and proteomics. This property is of great clinical importance in light of recent definitions of health and disease.
Conclusion: This review highlights the workflow of a typical metabolomics study and summarises the most up-to-date results obtained from the latest in vivo imaging techniques and their technologies, focussing on the future perspective of in vivo MRS metabolomics.
Metabolomics, in vivo imaging techniques, proteomics, NMR, metabolite, chemical species.
Department of Radiology, University of Cagliari, Cagliari, Department of Radiology, University of Cagliari, Cagliari, Department of Radiology, University of Cagliari, Cagliari, Department of Nuclear Medicine, University of Cagliari, Cagliari, Department of Radiology, University of Cagliari, Cagliari