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The Established Nuclear Medicine Modalities for Imaging of Bone Metastases

[ Vol. 15 , Issue. 9 ]

Author(s):

Nazish Jabeen, Rashid Rasheed, Asma Rafique and Ghulam Murtaza*   Pages 819 - 830 ( 12 )

Abstract:


Background: The skeleton is one of the frequent site of metastases in advanced cancer. Prostate, breast and renal cancers mostly metastasize to bone.

Discussion: Malignant tumors lead to significant morbidity and mortality. Identification of bone lesions is a crucial step in diagnosis of disease at early stage, monitoring of disease progression and evaluation of therapy. Diagnosis of cancer metastases is based on uptake of bone-targeted radioactive tracer at different bone remodeling sites.

Conclusion: This manuscript summarizes already established and evolving nuclear medicine modalities (e.g. bone scan, SPECT, SPECT/CT, PET, PET/CT) for imaging of bone metastases.

Keywords:

Malignant tumors, morbidity, mortality, bone lesion, diagnosis, cancer metastasis, radioactive tracer.

Affiliation:

Department of Pharmacy, COMSATS Institute of Information Technology Abbottabad, Abbottabad, Institute of Nuclear Medicines, Oncology and Radiations (INOR), Ayub Medical Hospital, Abbottabad, Department of Pharmacy, COMSATS Institute of Information Technology Abbottabad, Abbottabad, Department of Pharmacy, COMSATS Institute of Information Technology Abbottabad, Abbottabad

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