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In vivo Monitoring of Oxygen Levels in Human Brain Tumor Between Fractionated Radiotherapy Using Oxygen-enhanced MR Imaging

Author(s):

Junchao Qian*, Xiang Yu, Bingbing Li, Zhenle Fei, Xiang Huang, Peng Luo, Liwei Zhang, Zhiming Zhang, Jianjun Lou and Hongzhi Wang   Pages 1 - 6 ( 6 )

Abstract:


Background: It was known that the response of tumor cells to radiation is closely related to tissue oxygen level and fractionated radiotherapy allows reoxygenation of hypoxic tumor cells. Non-invasive mapping of tissue oxygen level may hold great importance in clinic. Objective: The aim of this study is to evaluate the role of oxygen-enhanced MR imaging in the detection of tissue oxygen levels between fractionated radiotherapy. Methods: A cohort of 10 patients with brain metastasis was recruited. Quantitative oxygen enhanced MR imaging was performed prior to, 30 minutes and 22 hours after first fractionated radiotherapy. Results: The ΔR1 (the difference of longitudinal relaxivity between 100% oxygen breathing and air breathing) increased in the ipsilateral tumor site and normal tissue by 242% and 152%, respectively, 30 minutes after first fractionated radiation compared to pre-radiation levels. Significant recovery of ΔR1 in the contralateral normal tissue (p < 0.05) was observed 22 hours compared to 30 minutes after radiation levels. Conclusion: R1-based oxygen-enhanced MR imaging may provide a sensitive endogenous marker for oxygen changes in the brain tissue between fractionated radiotherapy.

Keywords:

Oxygen level, brain tumor, oxygen-enhanced magnetic resonance imaging, fractionated , radiotherapy

Affiliation:

Chinese Academy of Sciences, Hefei Institutes of Physical Science, Hefei Cancer Hospital, Hefei, China; Anhui Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Chinese Academy of Sciences, Hefei, Chinese Academy of Sciences, Hefei Institutes of Physical Science, Hefei Cancer Hospital, Hefei, Chinese Academy of Sciences, Hefei Institutes of Physical Science, Hefei Cancer Hospital, Hefei, Chinese Academy of Sciences, Hefei Institutes of Physical Science, Hefei Cancer Hospital, Hefei, Chinese Academy of Sciences, Hefei Institutes of Physical Science, Hefei Cancer Hospital, Hefei, Chinese Academy of Sciences, Hefei Institutes of Physical Science, Hefei Cancer Hospital, Hefei, Chinese Academy of Sciences, Hefei Institutes of Physical Science, Hefei Cancer Hospital, Hefei, Chinese Academy of Sciences, Hefei Institutes of Physical Science, Hefei Cancer Hospital, Hefei, Chinese Academy of Sciences, Hefei Institutes of Physical Science, Hefei Cancer Hospital, Hefei, Chinese Academy of Sciences, Hefei Institutes of Physical Science, Hefei Cancer Hospital, Hefei, China; Anhui Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Chinese Academy of Sciences, Hefei



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