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Risk Factors for Different Grades of Lower Respiratory Tract Infections in Children Under Five Years Old with Measles: Based on Chest Radiography

Author(s):

Huanguo Li, Minming Zhang*, Qun Lao, Yushuang Ding, Kaiyu Zhao and Ruju Xu   Pages 1 - 7 ( 7 )

Abstract:


Background: Although measles epidemic has been controlled effectively after measles vaccination carried out, China is still the focus of measles epidemic. The lower respiratory tract infections (LRTIs) is the most common complication, and also the most common reason for the death of patients with measles.

Purpose: To analyze what clinical factors could affect the grades of LRTIs in children under five years old with measles.

Methods: Patients’ 13 clinical factors and chest radiography were analyzed retrospectively. Based on the chest radiography, the LRTIs were divided into 3 grades. The clinical factors and the grades of LRTIs were analyzed by ordered logistic regression analysis.

Results: There were 74 cases in grade 0, 77 cases in grade 1, 36 cases in grade 2. After univariate logistic regression analysis, there were 5 clinical factors whose P value were no more than 0.1, including the children’s course of disease before admission, co-infection other pathogens , vaccination , the first symptoms and gender. After ordinal logistic regression analysis, the course of disease before admission (OR = 1.134, 95%CI: 0.02 to 0.132), without vaccination (OR = 1.808, 95%CI: 0.063 to 1.120) and co-infected other pathogens other pathogens infections (OR = 1.618, 95%CI: 0.007 to 0.892) during different grades (P < 0.05).

Conclusions: There were three clinical factors, including long course of disease before admission, without measles vaccine and with other pathogens co-infections, as the independent risk factors for infecting advanced LRTIs in children with measles.

Keywords:

measles, child, lower respiratory tract infections, chest radiography

Affiliation:

Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; Department of Radiology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Department of Radiology, Hangzhou Children`s Hospital, Xiacheng District, Hangzhou, Zhejiang, Department of Radiology, Children`s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, Department of Radiology, Hangzhou Children`s Hospital, Xiacheng District, Hangzhou, Zhejiang, Department of Infectious Disease, Hangzhou Children`s Hospital, Xiacheng District, Hangzhou, Zhejiang



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