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Evaluation of the Reliability of Interim PET/CT in the Hodgkin Lymphoma

Author(s):

Rafet Eren, Cihan Gündoğan, Ceyda Aslan, Alper Koç, Mehmet Hilmi Doğu, Şermin Altındal, Osman Yokuş, Elif Suyanı and Tevfik Fikret Çermik*   Pages 1 - 6 ( 6 )

Abstract:


Introduction: Positron-emission tomography (PET)/computerized tomography (CT) with 18F-fludeoxyglucose (FDG) has been come into use for risk assessment of Hodgkin lymphoma (HL) patients in recent years. The aim of our study is to evaluate the reliability of interim PET results according to Deauville score (DS), and also compared to PET findings with tumor reduction on CT.

Material-Method: Forty-two HL patients (median 39, range 19-75 y, 27 M, 15 F) who were retrospectively evaluated with pre, interim and post-treatment PET/CT imaging. PET/CT imaging was obtained 60 min after the intravenous administration of 3.7-5.2 MBq/kg 18F-FDG.

Results: The negative predictive value of the interim PET was 89 %. Four (10.5 %) of the 38 interim PET-negative patients became post-treatment PET-positive. According to CT, 15 patients were in complete remission (CR), 27 (64.6 %) patients were in partial remission (PR) or stable disease (SD).

Conclusion: The negative predictive value of interim PET was not satisfactory considering the treatment rate of over 80% of HL. Additionally, high rate of interim PET-negative patients’ conversion to PET-positive post-treatment state was considered as unexpected.

Keywords:

Hodgkin Lymphoma, Interim PET, CT scan

Affiliation:

University of Health Sciences, Department of Hematology, Istanbul Training and Research Hospital, Istanbul, University of Health Sciences, Department of Nuclear Medicine, Istanbul Training and Research Hospital, Istanbul, University of Health Sciences, Department of Hematology, Istanbul Training and Research Hospital, Istanbul, University of Health Sciences, Department of Hematology, Istanbul Training and Research Hospital, Istanbul, University of Health Sciences, Department of Hematology, Istanbul Training and Research Hospital, Istanbul, University of Health Sciences, Department of Hematology, Istanbul Training and Research Hospital, Istanbul, University of Health Sciences, Department of Hematology, Istanbul Training and Research Hospital, Istanbul, University of Health Sciences, Department of Hematology, Istanbul Training and Research Hospital, Istanbul, University of Health Sciences, Department of Nuclear Medicine, Istanbul Training and Research Hospital, Istanbul



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