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Evaluation of LVDD by CCTA with Dual-source CT in Type 2 Diabetes Mellitus Patients

[ Vol. 16 , Issue. 3 ]

Author(s):

Zengfa Huang, Jianwei Xiao, Zuoqin Li, Yun Hu, Yuanliang Xie, Shutong Zhang* and Xiang Wang*   Pages 214 - 223 ( 10 )

Abstract:


Background: Left ventricular diastolic dysfunction (LVDD) is a common abnormality among patients in T2DM.

Aims: We aimed to evaluate the feasibility of coronary computed tomography angiography (CCTA) for the assessment of LVDD in type 2 diabetes mellitus (T2DM) patients.

Methods: 80 consecutive T2DM patients who were referred for a clinically dual-source CCTA examination to evaluate suspected coronary artery disease and also underwent 2D echocardiography within 7 days of CCTA inclusion and exclusion criteria, were performed. Correlation between CCTA and echocardiography was tested through linear regression and Bland-Altman analysis.

Results: In total, 60 T2DM patients were included for the analysis. Pearson correlation showed good correlation for E (r = 0.28; P = 0.028), E/A (r = 0.69; P < 0.01); E (r = -0.06; P = 0.776), E/A (r = 0.54; P = 0.003) and E (r = 0.64; P < 0.01), E/A (r = 0.83; P < 0.01) in three groups, respectively. Overall, diagnostic accuracy for assessment in CCTA of diastolic dysfunction was 79.76% (95% CI: 68%-91%), 71.43% (95% CI: 58%-85%) and 87.50 (95% CI: 79%-96%) in three groups.

Conclusion: The presented study proved that CCTA showed good correlations in the estimation of LV filling pressures compared with echocardiography in T2DM patients. Accordingly, retrospectively ECG-gated CCTA may provide valuable information on the evaluation of LVDD in T2DM patients.

Keywords:

Coronary computed tomography angiography, left ventricular diastolic dysfunction, echocardiography, type 2 diabetes mellitus, patients, cardiovascular disease.

Affiliation:

Department of Radiology, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, Wuhan, Department of Radiology, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, Wuhan, Department of Radiology, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, Wuhan, Department of Radiology, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, Wuhan, Department of Radiology, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, Wuhan, Department of Radiology, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, Wuhan, Department of Radiology, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, Wuhan

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