Submit Manuscript  

Article Details


Investigating the Optimal Echo Times for Quantitative Susceptibility Mapping of Basal Ganglia Nuclei in Healthy Brain

Author(s):

Wenping Fan, Xue Wang, Xingwen Zhang, Mengqi Liu, Qinglin Meng and Zhiye Chen*  

Abstract:


Background: Quantitative susceptibility mapping (QSM) technique had been used to measure the magnetic susceptibility of brain tissue in clinical practice. However, QSM presented echo-time (TE) dependence, and an appropriate number of echo-times (nTEs) for QSM became more important to obtain the reliable susceptibility value.

Objective: The aim of the study was to explore the optimal nTEs for quantitative susceptibility mapping (QSM) measurements of basal ganglia nuclei in healthy brain.

Methods: 3D multi-echo enhanced gradient recalled echo T2 star weighted angiography (ESWAN) sequence was acquired on a 3.0T MR scanner for QSM analysis. Regions of interests (ROIs) were drawn along the margin of head of caudate nucleus (HCN), putamen (Pu) and globus pallidus (GP). The mean susceptibility value and standard deviation of the ROIs were derived from the pixels within each region.

Results: CV analysis demonstrated that TE6, TE8 and TE14 ESWAN sequences presented consistent lower CV value (< 1) for QSM measure of HCN, Pu and GP. ANOVA identified that susceptibility value showed no significant difference between TE6 and TE8 in HCN, Pu and GP (P > 0.05). ICC analysis demonstrated that susceptibility value of TE6-TE8 had the highest ICC value compared with TE6-TE14 and TE8-TE14 in HCN, Pu and GP. Combined with the time-efficiency of MRI scanning, TE6 sequence could not only provide the reliable QSM measurement but also short imaging time.

Conclusions: The current study identified that the optimal nTEs of ESWAN was 6 TEs (2.9ms ~ 80.9ms) for QSM measurement of basal ganglia nuclei in healthy brain.

Keywords:

Basal Ganglia, Magnetic Resonance Imaging, Quantitative Susceptibility Mapping, Brain

Affiliation:

Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya 572013, Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya 572013, Department of Neurology, First Medical Center of Chinese PLA General Hospital, Beijing 100853, Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya 572013, Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya 572013, Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya 572013



Full Text Inquiry