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Myxofibrosarcoma: clinical and prognostic value of MRI features

Author(s):

Paolo Spinnato*, Andrea Sambri, Tomohiro Fujiwara, Luca Ceccarelli, Roberta Clinca, Manuel Ricardo Medellin, Massimiliano De Paolis, Davide Maria Donati and Giuseppe Bianchi   Pages 1 - 10 ( 10 )

Abstract:


Myxofibrosarcoma is one of the most common soft tissue sarcomas in the elderly. It is characterized by an extremely high rate of local recurrence, higher than other soft tissue tumors, and a relatively low risk of distant metastases.Magnetic resonance imaging (MRI) is the imaging modality of choice for the assessment of myxofibrosarcoma and plays a key role in the preoperative setting of these patients.MRI features associated with high risk of local recurrence are: high myxoid matrix content (water-like appearance of the lesions), high grade of contrast enhancement, presence of an infiltrative pattern (“tail sign”). On the other hand, MRI features associated with worse sarcoma specific survival are: large size of the lesion, deep location, high grade of contrast enhancement. Recognizing the above-mentioned imaging features of myxofibrosarcoma may be helpful to stratify the risk for local recurrence and disease-specific survival. Moreover, the surgical planning should be adjusted according to the MRI features

Keywords:

Magnetic resonance imaging, Sarcoma, Soft Tissue Neoplasm, Neoplasm Invasivenes, Prognosis, local neoplasm recurrence.

Affiliation:

Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Istituto Nacional de Cancerologia, Bogotà, Department of Orthopaedics, AOSP Sant’Orsola Malpighi, Bologna, Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna



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