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Computer Simulation of the Effects of Contrast Protocols on Aortic Signal Intensity on Magnetic Resonance Angiograms

[ Vol. 17 , Issue. 3 ]

Author(s):

Toru Higaki*, Yuko Nakamura, Fuminari Tatsugami, Wataru Fukumoto and Kazuo Awai   Pages 396 - 403 ( 8 )

Abstract:


Background: While iodine-enhanced computed tomography has been studied, detailed information on gadolinium-enhanced magnetic resonance imaging has not been reported.

Objective: We evaluated the effects of different gadolinium contrast agent (Gd-CA) factors on the enhancement of aortic magnetic resonance angiography (MRA) using computer simulation.

Methods: We developed computer-simulation software that combines pharmacokinetic models and tables; it converts the blood concentration of particular Gd-CAs into the signal intensity (SI). We simulated aortic time-intensity curves (TIC) in our MRA study and compared the effect of the Gd-- CA volume, injection rate, and of different Gd-CAs on the TIC.

Results: An increase in the Gd-CA volume from 14.0 to 28.0 ml increased maximal aortic intensity 1.11 times. Changing the injection rate from 1.0 to 2.8 ml/s increased it 1.10 times. The maximal SI of gadoterate-meglumine and gadobutrol was 1.03 and 1.01 times, respectively, that of gadoteridol.

Conclusion: In our computer-simulated MRA study, different Gd-CA factors resulted in no significant difference in the maximal aortic SI.

Keywords:

Gadolinium contrast agent, contrast-enhanced MR, MR angiography, computer simulation, contrast protocol, time-intensity curve.

Affiliation:

Department of Diagnostic Radiology, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Department of Diagnostic Radiology, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Department of Diagnostic Radiology, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Department of Diagnostic Radiology, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Department of Diagnostic Radiology, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551

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