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Osteosarcoma of the Jaws: A Literature Review

Author(s):

Francesco Ricotta, Massimo Bassi, Nicola Tomasetti, Angelo Campobassi, Vincenzo Maiolo, Franco Bertoni, Patrizia Bacchini, Claudio Marchetti and Achille Tarsitano*   Pages 1 - 11 ( 11 )

Abstract:


Osteosarcoma of the jaws (OSJ) is a relatively rare disease, accounting for between 2% and 10% of all cases of osteosarcoma, it is morphologically and radiologically identical to the trunk and extremity variant, but distinct in several crucial aspects. The lesion is characterized by sarcomatous cells which produces a variable amount of osteoid bone. It arises centrally within the bone and can be subdivided into osteoblastic, chondroblastic and fibroblastic subtype, depending on the predominant cell type. Radiographically, these tumors display a spectrum of bone changes from well-demarcated borders to lytic bone destruction with indefinite margins and variable cortical bone erosion or, in some cases, images of sclerotic bone. Therapeutic options for OSJ include surgery, chemotherapy and radiotherapy, which are employed according to age of the patient, histological classification and localization of the tumor. Today there is no a general consensus in the treatment guidelines for the OSJ though surgery represents the key of the treatment. The main prognostic factor deeply influencing the patient’s prognosis remains the complete tumor resection with negative surgical margins. The aim of the present review is to describe the state of the art regarding diagnostic and surgical treatment aspects of the primary osteosarcoma of the jaws.

Keywords:

Osteosarcoma, jaws, head and neck oncology, bone tumors, maxillary osteosarcoma, jaws neoplasms.

Affiliation:

Oral and Maxillofacial Surgery Unit, IRCCS Sant’Orsola, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Maxillofacial Surgery Unit, Bufalini Hospital, Cesena, Maxillofacial Surgery Unit, Bufalini Hospital, Cesena, Maxillofacial Surgery Unit, Bufalini Hospital, Cesena, Radiology Unit, IRCCS Sant’Orsola, Bologna, Villa Erbosa Hospital, Pathology Section, Bologna, Villa Erbosa Hospital, Pathology Section, Bologna, Oral and Maxillofacial Surgery Unit, IRCCS Sant’Orsola, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Oral and Maxillofacial Surgery Unit, IRCCS Sant’Orsola, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna



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