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Ovarian Granulosa Cell Tumor: A Clinicoradiologic Series with Literature Review

Author(s):

Yagmur Kilinc, Lutfullah Sari*, Huseyin Toprak, Mehmet Gultekin, Ummuhan Karabulut and Nurhan Sahin   Pages 1 - 8 ( 8 )

Abstract:


Background: Ovarian granulosa cell tumors that originate from the sex cord-stromal cells represent 2% to 5% of all ovarian cancers. These tumors constitute two subgroups according to their clinical and histopathological features: juvenile granulosa cell tumors (JGCT) and adult granulosa cell tumors (AGCT). Granulosa cell tumor (GCT) is considered to be a low-grade malignancy with a favorable prognosis.

Methods: This case series includes four patients who admitted to our university hospital and had an MRI examination within 5 years.

Results: The histopathological subtype of granulosa tumor was the adult type in 3 patients and juvenile type in 1 patient. Even though its extremely rare, bone metastases were present in one of our patients. Liver metastases were also detected in one patient. The MRI examination of tumors revealed a heterogeneous solid mass that contained cystic components in 3 patients. In one of our patients, the tumor had a multiseptated cystic feature, and all of the tumors were ovoid or round with smooth margins. T1 signal hyperintensity, not suppressed on fat saturation sequences, observed in our 3 patients, which represents its hemorrhagic content.

Conclusion: Even though granulosa cell tumor shows a wide spectrum in terms of tumor appearance, some common findings have been shown and especially a hemorrhagic content could be a clue for us. The tumor is known to have a good prognosis, but it may have an unpredictable clinical course, so close follow-up has a great importance.

Keywords:

Ovarian granulosa cell tumor, MRI, US, sex cord-stromal cells, juvenile granulosa cell tumors (JGCT), adult granulosa cell tumors (AGCT).

Affiliation:

Department of Radiology, Medical Faculty, Bezmialem Faundatiton University Hospital, Istanbul, Department of Radiology, Medical Faculty, Bezmialem Faundatiton University Hospital, Istanbul, Department of Radiology, Medical Faculty, Bezmialem Faundatiton University Hospital, Istanbul, Department of Radiology, Medical Faculty, Bezmialem Faundatiton University Hospital, Istanbul, Department of Radiology, Medical Faculty, Bezmialem Faundatiton University Hospital, Istanbul, Department of Pathology, Medical Faculty, Bezmialem Vakif University, Istanbul



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