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The evaluation of the maculopathy using dynamic contrast-enhanced MRI in patients with proliferative diabetic retinopathy

Author(s):

Zhiye Chen, Huan Xu, Mengqi Liu, Chunfang Li, Houbin Huang* and Lin Ma*  

Abstract:


Background: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) technique could not only quantify blood-retinal barrier (BRB) breakdown leading to macular edema associated with diabetes but also provide a two-dimensional imaging method that is not interfered by refracting media.

Objective: The current study was aimed to evaluate the macular change in patients with diabetic retinopathy using the DCE-MRI technique.

Methods: Twenty patients with diabetic retinopathy (DR) and 20 normal controls (NC) were included. The fast spoiled gradient-echo sequence was used to perform dynamic contrast T1WI enhancement on a 3.0T MR system. The assessments of the macular region, optic papilla, and nasal retina were performed with quantitative DCE-MRI evaluation using Omni-Kinetics software.

Results: The maximal concentration, the area under the concentration-time curve (AUCconcentration-time), and maximal slope of macular region were significantly higher in DR [0.270(0.03,1.20)mmol/100ml, 2.71(0.04,9.91) mmol*min, and 0.38(0.06,3.18) mmol/min, respectively] than that [0.169(0.03,0.72) mmol/、1.25(0.13,10.41) mmol*min, and 0.245(0.06,1.34) mmol/min] in NC (U value = 515.00 and P value = 0.080, U value = 433.00 and P value = 0.000, and U value = 563.00 and P value = 0.023, respectively). The receiver operating characteristic curve (ROC) analysis demonstrated that the area under AUCconcentration-time was 0.729±0.058 with the cut-off value of 1.479 mmol*min (sensitivity 80.00% and specificity 62.50%) for macular region.

Conclusion: The quantitative DCE-MRI technique could be used to evaluate the maculopathy associated with diabetic retinopathy.

Keywords:

Diabetic retinopathy, magnetic resonance imaging, macula lutea retinae, optic papilla

Affiliation:

Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya, Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya, Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya, Department of Radiology, First Medical Center of Chinese PLA General Hospital, Beijing 100853, Deapartment of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, Hainan 572013, Department of Radiology, First Medical Center of Chinese PLA General Hospital, Beijing 100853



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