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Evaluation of Aortic Distensibility in Patients with Nonalcoholic Fatty Liver using CT

Author(s):

Qianqian Yang, Zheng Wang, Zengfa Huang, Shutong Zhang, Yuanliang Xie and Xiang Wang*  

Abstract:


Background: Nonalcoholic fatty liver disease has attracted considerable attention with continuously increasing morbidity.

Objective: To evaluate the aortic distensibility in patients with non-diabetes and hypertension-type nonalcoholic fatty liver disease(NAFLD) through dual-source computed tomography(DSCT).

Method: 120 patients with NAFLD (experimental group) and 30 healthy subjects (control group) were consecutively enrolled in the study. In the two groups, aortic distensibility was calculated as follows: D = △A/(A0 ×△p). Record fasting insulin, fasting blood glucose, fasting lipid status, age, heart rate, waist circumference, systolic blood pressure, and diastolic blood pressure. Calculate homeostasis model assessment of insulin resistance (HOMA-IR) and body mass index (BMI). A comparative analysis between the two groups was carried out, followed by correlation analysis between D value and risk factors.

Results: D value and liver attenuation of the patients in the NAFLD group were significantly reduced relative to those in the control group (2.24±0.63×10-3mmHg-1 vs. 3.19±0.86×10-3mmHg-1, P<0.001 and 41±6HU vs. 53±5HU, P<0.001, respectively) and their fasting blood glucose, fasting insulin, triglyceride, low-density lipoprotein, aspartate aminotransferase, alanine transaminase, HOMA-IR, and BMI were higher than those in the control group. Liver attenuation, HOMA-IR, age, and BMI were significantly correlated with D value in the NAFLD group. The stepwise multiple linear regression analysis indicates that Liver attenuation and HOMA-IR were the significant risk factors for D value (β coefficient =0.43, P =0.001, and β coefficient =-0.33, P =0.02, respectively).

Conclusion: Patients with NAFLD suffer from a reduction in aortic distensibility, and insulin resistance may play a significant role in the early atherosclerosis stage.

Keywords:

Coronary computed tomography angiography, nonalcoholic fatty liver, aorta, liver disease, distensibility, cardiovascular disease

Affiliation:

Department of Radiology, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, Department of Radiology, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, Wuhan, Department of Radiology, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, Wuhan, Department of Radiology, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, Wuhan, Department of Radiology, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, Wuhan, Department of Radiology, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, Wuhan



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