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Ovarian Granulosa Cell Tumor: A Clinicoradiologic Series with Literature Review

[ Vol. 17 , Issue. 6 ]

Author(s):

Yagmur Basak Kilinc, Lutfullah Sari*, Huseyin Toprak, Mehmet Ali Gultekin, Ummuhan Ebru Karabulut and Nurhan Sahin   Pages 790 - 797 ( 8 )

Abstract:


Background: Ovarian granulosa cell tumors that originate from the sex cord-stromal cells represent 2% to 5% of all ovarian cancers. These tumors constitute two subgroups according to their clinical and histopathological features: juvenile granulosa cell tumors (JGCT) and adult granulosa cell tumors (AGCT). Granulosa cell tumor (GCT) is considered to be a low-grade malignancy with a favorable prognosis.

Methods: This case series includes four patients who were admitted to our university hospital and had an MRI examination within 5 years.

Results: The histopathological subtype of granulosa tumor was the adult type in 3 patients and juvenile type in 1 patient. Even though it is extremely rare, bone metastases were present in one of our patients. Liver metastases were also detected in one patient. The MRI examination of tumors revealed a heterogeneous solid mass that contained cystic components in 3 patients. In one of our patients, the tumor had a multiseptated cystic feature, and all of the tumors were ovoid or round with smooth margins. T1 signal hyperintensity, not suppressed on fat saturation sequences, was observed in 3 patients, which represents its hemorrhagic content.

Conclusion: Even though granulosa cell tumor shows a wide spectrum in terms of tumor appearance, some common findings have been shown and especially a hemorrhagic content could be a clue for us. The tumor is known to have a good prognosis, but it may have an unpredictable clinical course, so close follow-up is greatly important.

Keywords:

Ovarian granulosa cell tumor, MRI, US, sex cord-stromal cells, juvenile granulosa cell tumors (JGCT), adult granulosa cell tumors (AGCT).

Affiliation:

Department of Radiology, Medical Faculty, Bezmialem Faundatiton Vakif University Hospital, Istanbul, Department of Radiology, Medical Faculty, Bezmialem Faundatiton Vakif University Hospital, Istanbul, Department of Radiology, Medical Faculty, Bezmialem Faundatiton Vakif University Hospital, Istanbul, Department of Radiology, Medical Faculty, Bezmialem Faundatiton Vakif University Hospital, Istanbul, Department of Radiology, Medical Faculty, Bezmialem Faundatiton Vakif University Hospital, Istanbul, Department of Pathology, Medical Faculty, Bezmialem Vakif University, Istanbul

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