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Relationship with programmed cell death ligand 1 (PD-L1) and DTI features in brain metastases of non-small cell lung cancer; Preliminary study

Author(s):

Temel Fatih Yilmaz*, İsmail Yurtsever, Hacı Mehmet Turk, Mehmet Ali Gultekin, Mehmet Besiroglu, Dilek Hacer Cesme, Abdallah T M Shbair and Alpay Alkan  

Abstract:


Objectives: The purpose of the study was to determine DTI properties of brain metastases in subjects with non-small cell lung carcinoma (NSCLC), to evaluate whether there was a correlation between DTI findings and programmed cell death ligand-1 (PD-L1).

Methods: The study population (n:22) was assigned to PD-L1 negative (Group 1: PD-L1 expression<%50) (n=11) or positive (Group 2: PD-L1 expression ≥%50) (n=11). We compared ADC and FA values measured from the enhanced solid metastases and peritumoral edema area with PD-L1 protein status.

Results: The mean ADC values were lower in group 2 compared to group 1. The peritumoral ADC values were higher in group 2 compared to group 1. Mean peritumoral edema FA values are lower in group 2 compared to group 1. The peritumoral edema nADC values were higher in group 2 compared to group 1. As PD-L1 expression frequency increased, ADC values in the peritumoral edema area increased and FA values decreased.

Conclusions: We thought that the existence of PD-L1 protein doesn’t affect ADC and FA values of brain metastasis (BM) originating from NSCLC. DTI characteristics of the peritumoral edema area could be a guide in determining PD-L1 protein status of brain metastases of NSCLC. The relationship between PD-L1 expression status and DTI features in BM from NSCLC could help us to have an idea in response to immunotherapy.

Keywords:

Programmed cell death ligand 1, Diffusion tensor imaging, Brain metastasis, Non-small cell lung, Immunotherapy, Apparent diffusion coefficient

Affiliation:

Departments of Radiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Departments of Radiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Departments of Medical Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Departments of Radiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Departments of Medical Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Departments of Radiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Departments of Medical Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Departments of Radiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul



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