Submit Manuscript  

Article Details

T2/FLAIR Hyperintensity in Mesial Temporal Lobe: Challenging Differential Diagnosis


Sungjun Moon*   Pages 1 - 7 ( 7 )


T2/FLAIR hyperintensity in the mesial temporal lobe is the most common MR finding of herpes simplex encephalitis, but may be observed in other infectious and non-infectious diseases. The former includes herpes human virus 6 encephalitis, Japanese encephalitis, and neurosyphilis, and the latter autoimmune encephalitis, gliomatosis cerebri, bilateral or paradoxical posterior cerebral artery infarction, status epilepticus, and hippocampal sclerosis. Thus, T2/FLAIR hyperintensity in the mesial temporal lobe is not a disease-specific magnetic resonance imaging finding, and these conditions must be differentiated to ensure proper treatment. We review diseases that present with T2/FLAIR hyperintensity in the mesial temporal lobe and provide a helpful flow chart based on clinical and radiologic features.


Herpes simplex encephalitis , herpes human virus 6 encephalitis , Japanese encephalitis , neurosyphilis , autoimmune encephalitis , gliomatosis cerebri , status epilepticus , hippocampal sclerosis , ischemic stroke .


Department of Radiology, College of Medicine, Yeungnam University, Daegu

Read Full-Text article